(Q45317650)

English

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-446193)

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8 July 2022

dolichol-linked oligosaccharide biosynthetic process

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Asparagine N-linked glycosylation

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8 July 2022

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https://identifiers.org/reactome:R-HSA-446193

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Synthesis of substrates in N-glycan biosythesis

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Addition of N-acetyl-D-glucosamine to Dolichyl phosphate

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ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP

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Addition of a second mannose to the N-glycan precursor by ALG2

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Addition of the first mannose to the N-glycan precursor by ALG1

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ALG11 transfers the fourth and fifth Man to the N-glycan precursor

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ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1

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Flipping of the N-glycan precursor to inside the ER

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ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1

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Addition of a third mannose to the N-glycan precursor by ALG2

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ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1

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Addition of the first glucose to the N-glycan precursor by ALG6

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ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

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Addition of a second glucose to the N-glycan precursor by ALG8

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8 July 2022

Addition of a third glucose to the N-glycan precursor by an ALG10 homologue

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45317650)

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

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