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PINK1-PRKN Mediated Mitophagy
An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5205685)
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Statements
instance of
biological pathway
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
macroautophagy
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
part of
Mitophagy
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
exact match
https://identifiers.org/reactome:R-HSA-5205685
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
has part(s)
Pink1 is recruited from the cytoplasm to the mitochondria
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
Pink1 is cleaved on healthy mitochondria
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
Uncleaved Pink1 accumulates in damaged mitochondria
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
Pink1 recruits Parkin to the outer mitochondrial membrane.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
Parkin promotes the ubiquitination of mitochondrial substrates
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
p62 binds ubiquitinated mitochondrial substrates
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
p62 links damaged mitochondria to LC3
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
LC3 binds the autophagosome membrane Atg5-Atg12 complex
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
cites work
Mechanisms of mitophagy
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
Identifiers
Reactome ID
R-HSA-5205685
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-5205685
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