(Q45317882)

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Intraflagellar transport

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5620924)

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8 July 2022

intraciliary transport involved in cilium assembly

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https://identifiers.org/reactome:R-HSA-5620924

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Assembly of IFT A complex

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Assembly of IFT B complex

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TRIP11:IFT20 dissociates

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TRAF3IB1 recruits IFT20 to the IFT B complex from the Golgi

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TNPO1 binds KIF17 dimer

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KIF17 enters the cilium

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Assembly of the anterograde IFT train

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The anterograde IFT train dissociates

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Assembly of the retrograde IFT train

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The retrograde IFT train dissociates

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The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly

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A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis

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SnapShot: Intraflagellar transport

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Architecture and function of IFT complex proteins in ciliogenesis

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Cilia and Hedgehog responsiveness in the mouse

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Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

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Ciliogenesis: building the cell's antenna

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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

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Functional coordination of intraflagellar transport motors.

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The roles of evolutionarily conserved functional modules in cilia-related trafficking

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THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia

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Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles

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8 July 2022

Intraflagellar transport complex structure and cargo interactions

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Identifiers

1 reference

8 July 2022

(Q45317882)

Intraflagellar transport

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