(Q45318106)

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Nuclear signaling by ERBB4

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-1251985)

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8 July 2022

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8 July 2022

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https://identifiers.org/reactome:R-HSA-1251985

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8 July 2022

Cleavage of P-ERBB4jmA isoforms by ADAM17

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Cleavage of ERBB4m80 by gamma-scretase complex

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Translocation of ERBB4s80 to the nucleus

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8 July 2022

ERBB4s80 binds TAB2:NCOR1 complex

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8 July 2022

ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus

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8 July 2022

ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter

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8 July 2022

ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter

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8 July 2022

GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1

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S100B gene expression is inhibited by ERBB4:TAB2:NCOR1

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8 July 2022

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Translocation of ERBB4s80:YAP1 complex to the nucleus

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8 July 2022

ERBB4s80 binds STAT5A

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8 July 2022

ERBB4s80:STAT5A complex translocates to the nucleus

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8 July 2022

ERBB4s80:STAT5A binds CSN2 gene promoter

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8 July 2022

CSN2 gene expression is stimulated by ERBB4s80:STAT5A

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ERBB4s80 forms a complex with estrogen receptor ESR1

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ERBB4s80:ESR1 binds PGR gene promoter

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ERBB4s80:ESR1 binds CXCL12 gene promoter

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PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen

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CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen

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8 July 2022

Translocation of cytosolic ERBB4s80 to mitochondrial matrix

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8 July 2022

ERBB4s80:ESR1 binds ERBB4 gene promoter

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8 July 2022

ERBB4 gene expression is stimulated by ERBB4s80:ESR1

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8 July 2022

ERBB4s80 binds the APOE gene

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8 July 2022

APOE gene transcription is stimulated by ERBB4s80

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ERBB4s80 binds ADAP1 gene

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8 July 2022

ADAP1 gene expression is inhibited by ERBB4s80

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8 July 2022

ERBB4s80 binds SPARC gene

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8 July 2022

SPARC gene transcription is stimulated by ERBB4s80

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8 July 2022

ERBB4s80 binds STMN1 gene

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8 July 2022

STMN1 gene expression is stimulated by ERBB4s80

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8 July 2022

ERBB4s80 binds the MXD4 gene

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8 July 2022

MXD4 gene expression is stimulated by ERBB4s80

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8 July 2022

The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone

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8 July 2022

Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain

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8 July 2022

Prolactin and ErbB4/HER4 signaling interact via Janus kinase 2 to induce mammary epithelial cell gene expression differentiation

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8 July 2022

The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells

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8 July 2022

Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

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8 July 2022

Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src.

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8 July 2022

Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells

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8 July 2022

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

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8 July 2022

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

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8 July 2022

WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus

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8 July 2022

Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

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8 July 2022

Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment

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8 July 2022

Identifiers

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8 July 2022

(Q45318106)

Nuclear signaling by ERBB4

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