(Q45318290)

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MAPK6/MAPK4 signaling

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-5687128)

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MAPK family signaling cascades

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13 July 2022

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https://identifiers.org/reactome:R-HSA-5687128

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Activation of PAKs by RAC1 and CDC42

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Autophosphorylation of PAK1,2,3

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PAK1,2,3 phosphorylates MAPK6,4

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MAPK4,6 translocate to nucleus

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MAPK4,6 translocate to the cytoplasm

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MAPK6 is ubiquitinated at the N-terminal

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MAPK6 is degraded by the 26S proteasome

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CDK1 phosphorylates MAPK6

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CDC14A,B dephosphorylate p-3S,T MAPK6

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p-S MAPK6 phosphorylates NCOA3

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p-S857 NCOA3 binds ETV4

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p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter

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p-S MAPK6,4 binds MAPKAPK5

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p-S MAPK6,4 phosphorylate MAPKAPK5

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p-S MAPK6,4:p-T182 MAPKAPK5 translocate to the cytosol

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p-S182 MAPKAPK5 phosphorylates FOXO1

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p-S215 FOXO1 binds RAG gene

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p-S215 FOXO1 positively regulates RAG gene expression

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PKA phosphorylates MAPKAPK5

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p-S115 MAPKAPK5 translocates to the cytosol

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p-S MAPKAPK5 phosphorylates HSPB1

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p-T182 MAPKAPK5 binds DNAJB1

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p-T182-MAPKAPK5 phoshphorylates DNAJB1

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p-T182 MAPKAPK5 phosphorylates FOXO3

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p-S215 FOXO3 translocates to the nucleus

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p-S215 FOXO3 binds MIR34B and C gene

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FOXO3 regulates MIR34B,C expression

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MYC mRNA translation is negatively regulated by miR-34B and C

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MYC binds MAPKAPK5 gene

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MYC positively regulates MAPKAPK5 gene expression

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IGF2BP1 binds MAPK4 mRNA

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IGF2BP1 represses translation of MAPK4 mRNA

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SEPT7 binds p-S189 MAPK6 and p-T182 MAPKAPK5

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SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs

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p-S189 MAPK6:p-T182 MAPKAPK5 bind KALRN

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MAPKAPK5 phosphorylates KALRN

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JUN positively regulates MAPK6 gene expression

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Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

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Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

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The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression

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Cross-talk between protein kinase A and the MAPK-activated protein kinases RSK1 and MK5.

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Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

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ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion

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PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5.

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The Ser(186) phospho-acceptor site within ERK4 is essential for its ability to interact with and activate PRAK/MK5.

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Atypical mitogen-activated protein kinases: structure, regulation and functions

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Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

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Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5.

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N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

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Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

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Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

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More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

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8 July 2022

Identifiers

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8 July 2022

(Q45318290)

MAPK6/MAPK4 signaling

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