(Q45318304)

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Regulation of PTEN stability and activity

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-8948751)

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-8948751

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8 July 2022

AKT phosphorylates MKRN1

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8 July 2022

NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN

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8 July 2022

MKRN1 polyubiquitinates PTEN

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8 July 2022

TNKS and TNKS2 PARylate PTEN

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8 July 2022

RNF146 polyubiquitinates PARylated PTEN

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8 July 2022

Proteasome degrades polyubiquitinated PTEN

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8 July 2022

USP13 and OTUD3 deubiquitinate PTEN

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8 July 2022

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FRK phosphorylates PTEN

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8 July 2022

Casein kinase II phosphorylates PTEN

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8 July 2022

PREX2 binds PTEN and inhibits it

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8 July 2022

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8 July 2022

TRIM27 polyubiquitinates PTEN

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8 July 2022

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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8 July 2022

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

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8 July 2022

Direct identification of PTEN phosphorylation sites

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8 July 2022

NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

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8 July 2022

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

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8 July 2022

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

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8 July 2022

WWP2 is an E3 ubiquitin ligase for PTEN.

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8 July 2022

The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation

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8 July 2022

Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

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8 July 2022

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization

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8 July 2022

Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45318304)

Regulation of PTEN stability and activity

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