(Q45318440)

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COPI-dependent Golgi-to-ER retrograde traffic

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6811434)

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8 July 2022

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

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8 July 2022

Golgi-to-ER retrograde transport

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8 July 2022

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https://identifiers.org/reactome:R-HSA-6811434

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RAB:GTP recruits GBF1 to the Golgi membrane

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GBF1 recruits ARF:GDP to the Golgi

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GBF1 stimulates nucleotide exchange on ARF

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Active ARF recruits coatomer to the Golgi

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ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi

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ARFGAPs stimulate ARF GTPase activity at the Golgi membrane

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Retrograde COPI vesicles bind kinesin and microtubules

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Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs

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COPI vesicle uncoating at the ER

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NSF and SNAPs bind cis-SNARE at the ER membrane

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NSF ATPase activity dissociates cis-SNARE at the ER

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Moonlighting functions of the NRZ (mammalian Dsl1) complex

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Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum

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Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes

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Tethering the assembly of SNARE complexes

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Regulation of Golgi signaling and trafficking by the KDEL receptor.

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Reconstitution of retrograde transport from the Golgi to the ER in vitro

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The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi

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Retrograde traffic from the Golgi to the endoplasmic reticulum

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8 July 2022

The KDEL receptor: new functions for an old protein.

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q45318440)

COPI-dependent Golgi-to-ER retrograde traffic

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