(Q4734886)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35368

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35368&geneProductId=UniProtKB:P35368

1 reference

31 October 2017

adrenergic receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35368&geneProductId=UniProtKB:P35368

1 reference

5 June 2018

protein heterodimerization activity

1 reference

8 April 2019

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

alpha1-adrenergic receptor activity

Genomic organization and expression of the human alpha 1B-adrenergic receptor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

protein binding

IPI

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

integral component of plasma membrane

1 reference

5 June 2018

Genomic organization and expression of the human alpha 1B-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35368&geneProductId=UniProtKB:P35368

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

8 April 2019

8 April 2019

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

8 April 2019

caveola

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

regulation of muscle contraction

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

intracellular signal transduction

1 reference

8 April 2019

Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

glucose homeostasis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

5 June 2018

Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35368&geneProductId=UniProtKB:P35368

positive regulation of cytosolic calcium ion concentration

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

cell-cell signaling

1 reference

8 April 2019

Genomic organization and expression of the human alpha 1B-adrenergic receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

multicellular organism development

1 reference

1 January 2018

Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

phospholipase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

regulation of vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

positive regulation of vasoconstriction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

regulation of cardiac muscle contraction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

cell population proliferation

1 reference

1 January 2018

Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

positive regulation of smooth muscle contraction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

positive regulation of MAPK cascade

1 reference

8 April 2019

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

4 references

8 April 2019

8 April 2019

Chromosomal organization of adrenergic receptor genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

8 April 2019

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

neuron-glial cell signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35368

1 reference

8 April 2019

physically interacts with

ISS

1 reference

479

17 August 2016

1 reference

483

17 August 2016

1 reference

505

17 August 2016

1 reference

124

17 August 2016

1 reference

485

17 August 2016

1 reference

7109

17 August 2016

1 reference

9

17 August 2016

1 reference

38

17 August 2016

1 reference

277

17 August 2016

1 reference

7170

17 August 2016

1 reference

501

17 August 2016

1 reference

88

17 August 2016

1 reference

506

17 August 2016

1 reference

135

17 August 2016

1 reference

73

17 August 2016

1 reference

502

17 August 2016

1 reference

96

17 August 2016

1 reference

97

17 August 2016

1 reference

493

17 August 2016

1 reference

53

17 August 2016

1 reference

7302

17 August 2016

1 reference

499

17 August 2016

1 reference

503

17 August 2016

1 reference

99

17 August 2016

1 reference

488

English

17 August 2016

isoxsuprine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1197051

epinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

norepinephrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

(−)-ephedrine

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

methoxamine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201103

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

doxazosin mesylate

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200561

oxymetazoline hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

phenylephrine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200339

prazosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1558

tamsulosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200914

midodrine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200461

alfuzosin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1723

Gene Atlas image

PBB GE ADRA1B 207589 at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0