(Q4734891)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18825

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

protein homodimerization activity

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

signal transducer activity

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

adrenergic receptor activity

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

alpha-2A adrenergic receptor binding

IPI

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

alpha2-adrenergic receptor activity

IPI

3 references

8 April 2019

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

protein heterodimerization activity

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

2 references

integral component of plasma membrane

2 references

16 July 2018

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

16 July 2018

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

integral component of postsynaptic membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

integral component of postsynaptic density membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

integral component of plasma membrane

3 references

8 April 2019

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

G protein-coupled receptor signaling pathway

biological process

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

5 June 2018

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18825&geneProductId=UniProtKB:P18825

activation of protein kinase B activity

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

negative regulation of epinephrine secretion

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

regulation of sensory perception of pain

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

Molecular cloning, sequencing and functional study of the promoter region of the human alpha2C4-adrenergic receptor gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

negative regulation of norepinephrine secretion

TAS

negative regulation of uterine smooth muscle contraction

NAS

TAS

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

regulation of vasoconstriction

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

positive regulation of neuron differentiation

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

positive regulation of vasoconstriction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

positive regulation of MAPK cascade

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

adrenergic receptor signaling pathway

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

G protein-coupled receptor signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

receptor transactivation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18825

physically interacts with

IBA

1 reference

7117

17 August 2016

1 reference

5443

17 August 2016

1 reference

521

17 August 2016

1 reference

505

17 August 2016

1 reference

520

17 August 2016

1 reference

516

17 August 2016

1 reference

522

17 August 2016

1 reference

124

17 August 2016

1 reference

48

17 August 2016

1 reference

523

17 August 2016

1 reference

33

17 August 2016

1 reference

525

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

83

17 August 2016

1 reference

43

17 August 2016

1 reference

7461

17 August 2016

1 reference

7241

17 August 2016

1 reference

502

17 August 2016

1 reference

49

17 August 2016

1 reference

503

17 August 2016

1 reference

136

17 August 2016

1 reference

52

17 August 2016

1 reference

53

17 August 2016

1 reference

56

17 August 2016

1 reference

7310

17 August 2016

1 reference

499

17 August 2016

1 reference

102

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL677

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

apraclonidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200379

dipivefrin hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

oxymetazoline hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

dexmedetomidine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2106195

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0