(Q4763283)

angiopoietin-1

1 reference

Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

1 reference

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fibrinogen, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

receptor tyrosine kinase binding

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

IPI

8 April 2019

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

protein binding

IPI

1 reference

31 October 2017

Phospho-tyrosine dependent protein-protein interaction network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15389&geneProductId=UniProtKB:Q15389

signaling receptor binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

cell component

plasma membrane

1 reference

8 April 2019

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

microvillus

1 reference

8 April 2019

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

membrane raft

1 reference

8 April 2019

Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

extracellular exosome

1 reference

31 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15389&geneProductId=UniProtKB:Q15389

intracellular anatomical structure

1 reference

31 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q15389&geneProductId=UniProtKB:Q15389

extracellular exosome

HDA

1 reference

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of neuron apoptotic process

HDA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of protein phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of endothelial cell apoptotic process

1 reference

8 April 2019

Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of cell adhesion

1 reference

8 April 2019

Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

1 reference

8 April 2019

hemopoiesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of protein kinase B signaling

heparin biosynthetic process

1 reference

8 April 2019

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of receptor internalization

1 reference

8 April 2019

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

regulation of tumor necrosis factor production

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of cytokine production involved in immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of apoptotic process

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

1 reference

8 April 2019

positive regulation of endothelial cell migration

TAS

1 reference

8 April 2019

Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

1 reference

8 April 2019

cell-substrate adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

protein localization to cell surface

1 reference

8 April 2019

Lipid rafts serve as signaling platforms for Tie2 receptor tyrosine kinase in vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

angiogenesis

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of ERK1 and ERK2 cascade

regulation of macrophage migration inhibitory factor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

regulation of endothelial cell proliferation

1 reference

8 April 2019

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of phosphatidylinositol 3-kinase signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive chemotaxis

1 reference

8 April 2019

Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

activation of transmembrane receptor protein tyrosine kinase activity

1 reference

8 April 2019

Oligomerized Tie2 localizes to clathrin-coated pits in response to angiopoietin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

regulation of protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

regulation of skeletal muscle satellite cell proliferation

1 reference

8 April 2019

Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of protein ubiquitination

1 reference

8 April 2019

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

leukocyte migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

1 reference

8 April 2019

regulation of I-kappaB kinase/NF-kappaB signaling

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of protein import into nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of cell adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

negative regulation of vascular permeability

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

Tie signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

3 references

8 April 2019

8 April 2019

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

positive regulation of peptidyl-tyrosine phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

8 April 2019

Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q15389

Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

Gene Atlas image

PBB GE ANGPT1 205608 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

1 reference

Fibrinogen, conserved site

1 reference