(Q4812916)

English

Ataxin 1

mammalian protein found in Homo sapiens

ATXN1
alternative ataxin1
ataxin-1
spinocerebellar ataxia type 1 protein

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

poly(G) binding

determination method

1 reference

8 April 2019

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

protein self-association

determination method

1 reference

8 April 2019

Identification of a self-association region within the SCA1 gene product, ataxin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

2 references

protein C-terminus binding

determination method

protein binding

determination method

13 references

8 April 2019

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Development and application of a DNA microarray-based yeast two-hybrid system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

identical protein binding

determination method

5 references

8 April 2019

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

The AXH domain adopts alternative folds the solution structure of HBP1 AXH.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

poly(U) RNA binding

determination method

1 reference

8 April 2019

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

protein binding

determination method

14 references

1 January 2018

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Development and application of a DNA microarray-based yeast two-hybrid system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

protein C-terminus binding

determination method

3 references

1 January 2018

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

poly(U) RNA binding

determination method

identical protein binding

determination method

6 references

1 January 2018

The AXH domain adopts alternative folds the solution structure of HBP1 AXH.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

nuclear inclusion body

determination method

1 reference

8 April 2019

RNA association and nucleocytoplasmic shuttling by ataxin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

nuclear RNA export factor complex

determination method

1 reference

27 February 2018

RNA association and nucleocytoplasmic shuttling by ataxin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54253&geneProductId=UniProtKB:P54253

determination method

determination method

5 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

1 January 2018

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 gene product

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

biological process

determination method

1 reference

8 April 2019

RNA association and nucleocytoplasmic shuttling by ataxin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

RNA association and nucleocytoplasmic shuttling by ataxin-1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54253&geneProductId=UniProtKB:P54253

determination method

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54253&geneProductId=UniProtKB:P54253

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P54253&geneProductId=UniProtKB:P54253

determination method

brain development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

social behavior

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

lung alveolus development

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

nervous system development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

anatomical structure development

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P54253

determination method

Gene Atlas image

PBB GE ATXN1 203232 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000244769

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000244769

ENSP00000416360

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416360

ENSP00000493530

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493530

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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