(Q4862366)

Thyrotropin receptor

1 reference

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

BspA type Leucine rich repeat region, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

G protein-coupled peptide receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

3 references

8 April 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

protein-hormone receptor activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

signal transducer activity

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

thyroid-stimulating hormone receptor activity

3 references

27 March 2018

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

27 March 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

protein-containing complex binding

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

signaling receptor activity

IDA

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

thyroid-stimulating hormone receptor activity

4 references

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

GOA

curator

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

integral component of plasma membrane

IDA

1 reference

27 March 2018

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

intracellular anatomical structure

IDA

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

1 reference

8 April 2019

Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

G protein-coupled receptor signaling pathway

TAS

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

adenylate cyclase-activating G protein-coupled receptor signaling pathway

TAS

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

positive regulation of cell population proliferation

1 reference

8 April 2019

Germline mutations in the thyrotropin receptor gene cause non-autoimmune autosomal dominant hyperthyroidism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

activation of adenylate cyclase activity

TAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

hormone-mediated signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

nervous system development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

cell surface receptor signaling pathway

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

positive regulation of adenylate cyclase activity

1 reference

1 January 2018

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16473&geneProductId=UniProtKB:P16473

cellular response to glycoprotein

1 reference

8 April 2019

Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

cellular response to thyrotropin-releasing hormone

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

thyroid-stimulating hormone signaling pathway

1 reference

8 April 2019

Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

adenylate cyclase-activating G protein-coupled receptor signaling pathway

positive regulation of cold-induced thermogenesis

1 reference

8 April 2019

Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16473

physically interacts with

ISS

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201533

Gene Atlas image

PBB GE TSHR 210055 at fs.png
732 × 530; 10 KB

0 references

exact match

http://purl.uniprot.org/uniprot/P16473

1 reference

BspA type Leucine rich repeat region

Identifiers.org

has part(s)

1 reference

GPCR, rhodopsin-like, 7TM

1 reference