(Q50285987)

English

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-187552)

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Statements

1 reference

8 July 2022

SCF(Skp2)-mediated degradation of p27/p21

1 reference

13 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-187552

1 reference

8 July 2022

CUL1:SKP1:SKP2:CKS1B [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm]

quantity

1

object of statement has role

1 reference

8 July 2022

Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase

1 reference

8 July 2022

Noncatalytic requirement for cyclin A-cdk2 in p27 turnover

1 reference

8 July 2022

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

1 reference

8 July 2022

The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50285987)

Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex

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