(Q50287563)

English

RhoGTPase GEF's recruited to DCC

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-418858)

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Statements

biological process

1 reference

8 July 2022

DCC mediated attractive signaling

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-418858

1 reference

8 July 2022

DOCK1,TRIO [cytosol]

1

object has role

1 reference

8 July 2022

NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane]

1

object has role

1 reference

8 July 2022

NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane]

1

object has role

1 reference

8 July 2022

The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.

1 reference

8 July 2022

Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling

1 reference

8 July 2022

Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.

1 reference

8 July 2022

Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion

1 reference

8 July 2022

The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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