(Q50288780)

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Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5655347)

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8 July 2022

Signaling by FGFR4 in disease

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-5655347

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8 July 2022

p21 RAS:GDP [plasma membrane]

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1

object of statement has role

1 reference

8 July 2022

p21 RAS:GTP [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

1 reference

8 July 2022

Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform

1 reference

8 July 2022

FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer

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8 July 2022

Fibroblast growth factors and their receptors in cancer

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8 July 2022

The FGFR4 Y367C mutant is a dominant oncogene in MDA-MB453 breast cancer cells

1 reference

8 July 2022

Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation

1 reference

8 July 2022

Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations

1 reference

8 July 2022

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

1 reference

8 July 2022

Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer

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8 July 2022

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival

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8 July 2022

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50288780)

Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange

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