(Q50289584)

English

botE HC:LC binds SV2A or B and GT1b on the target cell surface

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-5244503)

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Statements

biological process

1 reference

8 July 2022

Toxicity of botulinum toxin type E (botE)

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-5244503

1 reference

8 July 2022

botE HC:LC dimer [extracellular region]

1

object has role

1 reference

8 July 2022

ganglioside GT1b

1

object has role

1 reference

8 July 2022

SV2A,B [plasma membrane]

1

object has role

1 reference

8 July 2022

botE:SV2:GT1b [plasma membrane]

1

object has role

1 reference

8 July 2022

Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation

1 reference

8 July 2022

Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.

1 reference

8 July 2022

Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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