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TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2681667)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
part of
ECM proteoglycans
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
exact match
https://identifiers.org/reactome:R-HSA-2681667
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
has part(s)
Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
Tenascin-C hexamer [extracellular region]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
cites work
Differential effects of the integrins alpha9beta1, alphavbeta3, and alphavbeta6 on cell proliferative responses to tenascin. Roles of the beta subunit extracellular and cytoplasmic domains
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
Tenascin-C inhibits beta1 integrin-dependent cell adhesion and neurite outgrowth on fibronectin by a disialoganglioside-mediated signaling mechanism
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
Endothelial cell attachment and spreading on human tenascin is mediated by alpha 2 beta 1 and alpha v beta 3 integrins
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
Identifiers
Reactome ID
R-HSA-2681667
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-2681667
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