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IRAK1 phosphorylates Pellino
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-937034)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
part of
IRAK1 recruits IKK complex
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
exact match
https://identifiers.org/reactome:R-HSA-937034
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
has part(s)
ATP(4-)
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
TRAF6:hp-IRAK1:Pellino [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
ADP(3-)
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
p-Pellino:hp-IRAK1:TRAF6 [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
TRAF6:hp-IRAK1:Pellino [plasma membrane]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
cites work
Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
Identifiers
Reactome ID
R-HSA-937034
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-937034
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