(Q50291752)

English

Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-177690)

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Statements

biological process

1 reference

8 July 2022

TICAM1,TRAF6-dependent induction of TAK1 complex

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-177690

1 reference

8 July 2022

TAB1:TAB2,TAB3:TAK1 [cytosol]

2

object has role

1 reference

8 July 2022

viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]

1

object has role

1 reference

8 July 2022

viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]

1

object has role

1 reference

8 July 2022

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR

1 reference

8 July 2022

Ubiquitin-mediated activation of TAK1 and IKK.

1 reference

8 July 2022

Direct activation of protein kinases by unanchored polyubiquitin chains

1 reference

8 July 2022

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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