(Q50292417)

English

Activation of JAK kinases

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-909729)

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Statements

biological process

1 reference

8 July 2022

Interferon alpha/beta signaling

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-909729

1 reference

8 July 2022

3

object has role

1 reference

8 July 2022

IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane]

1

object has role

1 reference

8 July 2022

3

object has role

1 reference

8 July 2022

IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane]

1

object has role

1 reference

8 July 2022

IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane]

1

object has role

1 reference

8 July 2022

p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane]

1

object has role

1 reference

8 July 2022

Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase

1 reference

8 July 2022

A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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