(Q50293268)

English

EXT1:EXT2 transfers GlcA to heparan

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-2076392)

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Statements

biological process

1 reference

8 July 2022

HS-GAG biosynthesis

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-2076392

1 reference

8 July 2022

Heparan(2)-PGs [Golgi lumen]

1

object has role

1 reference

8 July 2022

Heparan(3)-PGs [Golgi lumen]

1

object has role

1 reference

8 July 2022

EXT1:EXT2 [Golgi membrane]

1

object has role

1 reference

8 July 2022

UDP-alpha-D-glucuronate(3-)

1

object has role

1 reference

8 July 2022

1

object has role

1 reference

8 July 2022

Mutations in the EXT1 and EXT2 genes in hereditary multiple exostoses

1 reference

8 July 2022

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

1 reference

8 July 2022

Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytes

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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