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English
CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-212004)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
part of
Xenobiotics
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
exact match
https://identifiers.org/reactome:R-HSA-212004
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
has part(s)
hydron
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
NADPH
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
dioxygen
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
phenytoin
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
water
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
4-hydroxyphenytoin
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
NADP+
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
Cytochrome P450 (CYP2C18 based) [endoplasmic reticulum membrane]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
cites work
P450 2C18 catalyzes the metabolic bioactivation of phenytoin.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
Identifiers
Reactome ID
R-HSA-212004
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-212004
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