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CYP3A4 can N-demethylate loperamide
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-211948)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
part of
Xenobiotics
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
exact match
https://identifiers.org/reactome:R-HSA-211948
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
has part(s)
hydron
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
loperamide
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
NADPH
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
dioxygen
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
water
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
desmethyl loperamide
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
NADP+
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
Cytochrome P450 (CYPIIIA4 based) [endoplasmic reticulum membrane]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
cites work
Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
Identifiers
Reactome ID
R-HSA-211948
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-211948
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