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SHPRH polyubiquitinates monoubiquitinated PCNA
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-8943003)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
part of
E3 ubiquitin ligases ubiquitinate target proteins
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
exact match
https://identifiers.org/reactome:R-HSA-8943003
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
has part(s)
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
Ub:UBE2N:UBE2V2 [nucleoplasm]
quantity
8
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
K63polyUb-K164-PCNA homotrimer [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
RAD18:UBE2B [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
SNF2 histone linker PHD RING helicase
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
UBE2N:UBE2V2 [nucleoplasm]
quantity
9
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
SHPRH:monoUb:K164-PCNA:RAD18:UBE2B:Ub:UBE2N:UBE2V2 [nucleoplasm]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
cites work
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
Identifiers
Reactome ID
R-HSA-8943003
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-8943003
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