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Binding of PI3K to ERBB2:p-ERBB3 heterodimer
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1250189)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
part of
PI3K events in ERBB2 signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
exact match
https://identifiers.org/reactome:R-HSA-1250189
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
has part(s)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
PIK3CA:PIK3R1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
cites work
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
Mapping ErbB receptors on breast cancer cell membranes during signal transduction.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
Identifiers
Reactome ID
R-HSA-1250189
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1250189
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