(Q50298655)

English

Phosphorylated NICD1 binds FBXW7

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1912385)

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Statements

biological process

1 reference

8 July 2022

NOTCH1 Intracellular Domain Regulates Transcription

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-1912385

1 reference

8 July 2022

FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]

1

object has role

1 reference

8 July 2022

p-NICD1 [nucleoplasm]

1

object has role

1 reference

8 July 2022

p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]

1

object has role

1 reference

8 July 2022

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

1 reference

8 July 2022

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

1 reference

8 July 2022

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

1 reference

8 July 2022

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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