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Ubiquitination of NICD1 by FBWX7
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1852623)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
part of
NOTCH1 Intracellular Domain Regulates Transcription
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
exact match
https://identifiers.org/reactome:R-HSA-1852623
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
has part(s)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
Ub [nucleoplasm]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
Ub-p-NICD1 [nucleoplasm]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
quantity
1
object has role
modifier
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
cites work
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
Identifiers
Reactome ID
R-HSA-1852623
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-1852623
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