(Q50298664)

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NOTCH2-ligand complex is cleaved to produce NEXT2

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-157629)

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1 reference

8 July 2022

NOTCH2 Activation and Transmission of Signal to the Nucleus

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-157629

1 reference

8 July 2022

Ub-DLL/JAG:NOTCH2 [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

1

object of statement has role

1 reference

8 July 2022

NOTCH2 fragment:DLL/JAG [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

ADAM10:Zn2+ [plasma membrane]

quantity

1

object of statement has role

1 reference

8 July 2022

Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2

1 reference

8 July 2022

Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin

1 reference

8 July 2022

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

1 reference

8 July 2022

Regulated proteolysis of NOTCH2 and NOTCH3 receptors by ADAM10 and presenilins

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50298664)

NOTCH2-ligand complex is cleaved to produce NEXT2

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