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RSPOs bind LGRs
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-4641206)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
part of
Regulation of FZD by ubiquitination
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
exact match
https://identifiers.org/reactome:R-HSA-4641206
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
has part(s)
LGR [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
RSPO [extracellular region]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
RSPO:LGR [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
cites work
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
Mitogenic influence of human R-spondin1 on the intestinal epithelium
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
R-Spondin proteins: a novel link to beta-catenin activation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
Identifiers
Reactome ID
R-HSA-4641206
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-4641206
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