(Q5262653)

http://www.ebi.ac.uk/interpro/protein/Q9BUN8

Endoplasmic Reticular Retrotranslocon

0 references

1 reference

13 November 2019

1 reference

13 November 2019

12 references

8 April 2019

The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

UBXD1 is a VCP-interacting protein that is involved in ER-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

USP14 inhibits ER-associated degradation via interaction with IRE1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

MHC class I protein binding

1 reference

8 April 2019

A membrane protein required for dislocation of misfolded proteins from the ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

ubiquitin protein ligase binding

1 reference

8 April 2019

RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

protease binding

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

ubiquitin-specific protease binding

1 reference

8 April 2019

Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

ATPase binding

2 references

8 April 2019

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

signaling receptor activity

NAS

1 reference

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

NAS

cell component

early endosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

VCP-NPL4-UFD1 AAA ATPase complex

1 reference

8 April 2019

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

integral component of endoplasmic reticulum membrane

1 reference

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

Derlin-1-VIMP complex

1 reference

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

late endosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

Derlin-1 retrotranslocation complex

3 references

8 April 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

endoplasmic reticulum

Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein required for dislocation of misfolded proteins from the ER

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein required for dislocation of misfolded proteins from the ER

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

signal recognition particle receptor complex

1 reference

8 April 2019

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

signal recognition particle

1 reference

8 April 2019

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

Unfolded Protein Response

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

endoplasmic reticulum unfolded protein response

1 reference

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

ERAD pathway

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

positive regulation of protein binding

1 reference

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

1 reference

8 April 2019

protein destabilization

1 reference

8 April 2019

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

retrograde protein transport, ER to cytosol

Identification of ERAD components essential for dislocation of the null Hong Kong variant of α-1-antitrypsin (NHK)

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein required for dislocation of misfolded proteins from the ER

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

1 reference

8 April 2019

ER-associated misfolded protein catabolic process

1 reference

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

protein homooligomerization

1 reference

8 April 2019

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

positive regulation of protein ubiquitination

1 reference

8 April 2019

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

establishment of protein localization

1 reference

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

ubiquitin-dependent ERAD pathway

The unfolded protein response: integrating stress signals through the stress sensor IRE1α

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

BAP31 interacts with Sec61 translocons and promotes retrotranslocation of CFTRDeltaF508 via the derlin-1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

8 April 2019

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

protein folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

1 reference

8 April 2019

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

1 reference

8 April 2019

protein ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

1 reference

8 April 2019

transport

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BUN8&geneProductId=UniProtKB:Q9BUN8

1 reference

17 October 2017

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BUN8

Transporter Classification Database ID

Gene Atlas image

PBB GE DERL1 218172 s at fs.png
732 × 530; 11 KB

0 references

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

3.A.16.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database