(Q5264821)

English

Desmoplakin

mammalian protein found in Homo sapiens

250/210 kDa paraneoplastic pemphigus antigen
DSP
desmoplakin

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein-macromolecule adaptor activity

determination method

1 reference

1 January 2018

Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

scaffold protein binding

determination method

1 reference

8 April 2019

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

structural molecule activity

determination method

1 reference

31 October 2017

Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

structural constituent of cytoskeleton

determination method

1 reference

8 April 2019

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

protein binding

determination method

5 references

8 April 2019

Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Disease mutations in desmoplakin inhibit Cx43 membrane targeting mediated by desmoplakin-EB1 interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication

determination method

1 reference

8 April 2019

Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

cell adhesion molecule binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

protein kinase C binding

determination method

1 reference

8 April 2019

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

31 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

structural molecule activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

intercalated disc

determination method

5 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

plasma membrane

determination method

5 references

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

basolateral plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

fascia adherens

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

extracellular exosome

determination method

4 references

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

determination method

2 references

determination method

1 reference

31 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

extracellular matrix

determination method

1 reference

31 October 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

ficolin-1-rich granule membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

intermediate filament

determination method

3 references

8 April 2019

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

plasma membrane

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

E-cadherin and plakoglobin recruit plakophilin3 to the cell border to initiate desmosome assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

intercalated disc

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Mutated desmoglein-2 proteins are incorporated into desmosomes and exhibit dominant-negative effects in arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Detection of genomic deletions of PKP2 in arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

extracellular exosome

determination method

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

biological process

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

bundle of His cell-Purkinje myocyte adhesion involved in cell communication

determination method

1 reference

8 April 2019

Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

keratinocyte differentiation

determination method

1 reference

8 April 2019

Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

peptide cross-linking

determination method

1 reference

8 April 2019

Small proline-rich protein 1 is the major component of the cell envelope of normal human oral keratinocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

epidermis development

determination method

1 reference

8 April 2019

Haploinsufficiency of desmoplakin causes a striate subtype of palmoplantar keratoderma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

intermediate filament cytoskeleton organization

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

adherens junction organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

regulation of heart rate by cardiac conduction

determination method

1 reference

8 April 2019

Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

regulation of ventricular cardiac muscle cell action potential

determination method

1 reference

8 April 2019

Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

skin development

determination method

1 reference

31 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15924&geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15924

determination method

cell-cell adhesion

determination method

Gene Atlas image

PBB GE DSP 200606 at fs.png
732 × 530; 11 KB

0 references

Spectrin/alpha-actinin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15924

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15924

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15924

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000396591

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396591

ENSP00000369129

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369129

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(7 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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