(Q5279726)

http://www.ebi.ac.uk/interpro/protein/P16444

Metal-dependent hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16444

Membrane dipeptidase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

metallodipeptidase activity

zinc ion binding

1 reference

8 April 2019

Dipeptide hydrolysis by the dinuclear zinc enzyme human renal dipeptidase: mechanistic insights from DFT calculations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

cysteine-type endopeptidase inhibitor activity involved in apoptotic process

1 reference

8 April 2019

Cilastatin attenuates cisplatin-induced proximal tubular cell damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

GPI anchor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

modified amino acid binding

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

metallopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

dipeptidyl-peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

dipeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

plasma membrane

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

4 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

26 September 2017

26 September 2017

Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

apical part of cell

1 reference

8 April 2019

DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

apical plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

anchored component of membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

extracellular exosome

4 references

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

26 September 2017

Intestinal epithelial cells secrete exosome-like vesicles

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16444&geneProductId=UniProtKB:P16444

microvillus membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

extracellular space

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

plasma membrane

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

8 April 2019

8 April 2019

Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

IBA

extracellular exosome

3 references

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

8 April 2019

Intestinal epithelial cells secrete exosome-like vesicles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

cellular response to calcium ion

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

Cilastatin attenuates cisplatin-induced proximal tubular cell damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

leukotriene metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

glutathione metabolic process

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

antibiotic metabolic process

1 reference

8 April 2019

Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

negative regulation of apoptotic process

1 reference

8 April 2019

Cilastatin attenuates cisplatin-induced proximal tubular cell damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

negative regulation of cell migration

1 reference

8 April 2019

DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

xenobiotic metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

cellular response to nitric oxide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

1 reference

8 April 2019

homocysteine metabolic process

1 reference

8 April 2019

Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

cellular lactam catabolic process

1 reference

8 April 2019

Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

apoptotic process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16444

Membrane dipeptidase, active site

Gene Atlas image

PBB GE DPEP1 205983 at fs.png
732 × 530; 10 KB

0 references

has part(s)

1 reference

InterPro Release 71.0