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Growth differentiation factor 3
mammalian protein found in Homo sapiens
uniprot:Q9NR23
GDF3
growth/differentiation factor 3
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NR23
part of
Transforming growth factor-beta-related
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NR23
Cystine-knot cytokine
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NR23
Transforming growth factor-beta, C-terminal domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
TGF-beta, propeptide family
1 reference
based on heuristic
inferred from protein domain or family
Transforming growth factor beta, conserved site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Homo sapiens
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NR23
encoded by
GDF3
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NR23
molecular function
cytokine activity
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
transforming growth factor beta receptor binding
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
growth factor activity
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
protein kinase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IPI
cell component
extracellular region
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
extracellular space
determination method
IBA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
cytoplasm
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
retrieved
8 April 2019
stated in
The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IDA
biological process
eye development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IMP
response to dietary excess
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
regulation of apoptotic process
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
skeletal system development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IMP
regulation of cell fate commitment
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IDA
negative regulation of myoblast differentiation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
endoderm development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
regulation of MAPK cascade
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
SMAD protein signal transduction
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
cell development
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
somite rostral/caudal axis specification
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
positive regulation of pathway-restricted SMAD protein phosphorylation
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
notochord development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
formation of anatomical boundary
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
in utero embryonic development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
negative regulation of BMP signaling pathway
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IDA
negative regulation of epidermal cell differentiation
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IDA
mesoderm development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
primitive streak formation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
multicellular organism development
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9NR23
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
positive regulation of fat cell differentiation
determination method
IEA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
regulation of signaling receptor activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Gene Ontology Consortium
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IEA
BMP signaling pathway
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NR23
determination method
IBA
has part(s)
Transforming growth factor beta, conserved site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NR23
Transforming growth factor-beta, C-terminal
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NR23
TGF-beta, propeptide
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9NR23
Identifiers
MeSH descriptor ID
D055451
0 references
RefSeq protein ID
NP_065685
1 reference
stated in
NCBI Gene
retrieved
30 May 2020
Entrez Gene ID
9573
UniProt protein ID
Q9NR23
1 reference
stated in
UniProt
retrieved
13 November 2019
UniProt protein ID
Q9NR23
Ensembl protein ID
ENSP00000331745
1 reference
stated in
Ensembl Release 99
Ensembl protein ID
ENSP00000331745
UMLS CUI
C0657189
1 reference
based on heuristic
inferred by common MeSH mappings on source and on Wikidata
stated in
UMLS 2023
retrieved
25 May 2023
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(0 entries)
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Wikivoyage
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Wiktionary
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Multilingual sites
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