(Q55230756)

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Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-9027604)

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long-chain fatty acid biosynthetic process

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Biosynthesis of specialized proresolving mediators (SPMs)

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https://identifiers.org/reactome:R-HSA-9027604

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Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA

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PTGS2 dimer oxidises DHA to 13-HDHA

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Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)

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Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA

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ALOX5 oxidises DHA to 7-HDHA

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5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA

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oxo-DHAs translocate from cytosol to extracellular region

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Ac-PTGS2 dimer oxidises DPAn-3 to 17-HDPAn-3

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Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3

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Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3

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ALOX5 oxidises DPAn-3 to 7-HDPAn-3

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5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3

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oxo-DPAn-3s translocate from cytosol to extracellular region

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ALOX5 oxidises EPA to 5-HEPE

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5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA

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PTGS2 dimer oxidises EPA to PGH3

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PGH3 spontaneously dehydrates to PGJ3

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PGJ3 isomerises to δ12-PGJ3

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δ12-PGJ3 spontaneously dehydrates to 15d-PGJ3

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5-oxo-EPA, 15d-PGJ3 translocate from cytosol to extracellular region

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Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q55230756)

Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives

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