(Q5864340)

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

1 reference

PAS domain superfamily

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family

1 reference

HD/PDEase domain, protein family

1 reference

3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family

1 reference

PAS fold family

1 reference

PAS domain, protein family

1 reference

phosphoric diester hydrolase activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

1 reference

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

3',5'-cyclic-nucleotide phosphodiesterase activity

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

3',5'-cyclic-AMP phosphodiesterase activity

IEA

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

1 January 2018

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

3',5'-cyclic-GMP phosphodiesterase activity

IBA

1 reference

8 April 2019

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

3',5'-cyclic-AMP phosphodiesterase activity

IDA

3 references

8 April 2019

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

Large-scale proteomics and phosphoproteomics of urinary exosomes

TAS

extracellular exosome

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

Large-scale proteomics and phosphoproteomics of urinary exosomes

IDA

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

cyclic nucleotide metabolic process

HDA

biological process

1 reference

31 October 2017

Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O60658&geneProductId=UniProtKB:O60658

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

NAS

cAMP catabolic process

1 reference

8 April 2019

regulation of transcription, DNA-templated

IEA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

positive regulation of protein phosphorylation

IEA

1 reference

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

negative regulation of cell death

IMP

1 reference

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

negative regulation of hydrogen peroxide-induced cell death

IMP

1 reference

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

G protein-coupled receptor signaling pathway

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

positive regulation of ERK1 and ERK2 cascade

TAS

3 references

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

cellular response to epidermal growth factor stimulus

IBA

3 references

8 April 2019

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60658

physically interacts with

IBA

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4807

language of work or name

English

retrieved

17 August 2016

flavoxate hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200875

EC enzyme number

3.1.4.53

1 reference

imported from Wikimedia project

Spanish Wikipedia

has part(s)

3'5'-cyclic nucleotide phosphodiesterase, conserved site

1 reference

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

1 reference

HD/PDEase domain

1 reference

PAS fold

1 reference

PAS domain

1 reference