Wikidata

(Q6449560)

English

Potassium voltage-gated channel subfamily Q member 1

mammalian protein found in Homo sapiens

  • KQT-like 1
  • potassium voltage-gated channel subfamily KQT member 1
  • potassium channel, voltage gated KQT-like subfamily Q, member 1
  • kidney and cardiac voltage dependend K+ channel
  • slow delayed rectifier channel subunit
  • potassium voltage-gated channel, KQT-like subfamily, member 1
  • IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
  • KCNQ1
  • voltage-gated potassium channel subunit Kv7.1
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No label defined

No description defined

Statements

molecular function
voltage-gated potassium channel activity
determination method or standard
IEA
IDA
7 references
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
24 April 2018
stated in
Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
transmembrane transporter binding
determination method or standard
IPI
5 references
retrieved
8 April 2019
stated in
Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
delayed rectifier potassium channel activity
determination method or standard
IDA
9 references
retrieved
24 April 2018
stated in
A molecular mechanism for adrenergic-induced long QT syndrome
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Mutations in the hminK gene cause long QT syndrome and suppress IKs function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
KCNQ1 gain-of-function mutation in familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
protein binding
determination method or standard
IPI
5 references
retrieved
8 April 2019
stated in
Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
retrieved
8 April 2019
stated in
Intracellular domains interactions and gated motions of I(KS) potassium channel subunits
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IPI
voltage-gated potassium channel activity
determination method or standard
IBA
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
8 April 2019
stated in
Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IBA
delayed rectifier potassium channel activity
determination method or standard
IBA
IDA
10 references
retrieved
8 April 2019
stated in
A molecular mechanism for adrenergic-induced long QT syndrome
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
KCNQ1 gain-of-function mutation in familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mutations in the hminK gene cause long QT syndrome and suppress IKs function
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IBA
cell component
voltage-gated potassium channel complex
determination method or standard
IC
IEA
IDA
5 references
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
24 April 2018
stated in
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
24 April 2018
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787
determination method or standard
IC
plasma membrane
determination method or standard
IEA
IDA
TAS
9 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
8 April 2019
stated in
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Kv7.1 surface expression is regulated by epithelial cell polarization
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
A constitutively open potassium channel formed by KCNQ1 and KCNE3
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndrome
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
A molecular mechanism for adrenergic-induced long QT syndrome
GOA
curator
UniProt
UniProt protein ID
P51787
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
voltage-gated potassium channel complex
determination method or standard
IBA
IC
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IEA
retrieved
8 April 2019
stated in
Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IDA
retrieved
8 April 2019
stated in
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IC
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787
determination method or standard
IBA
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q6449560&oldid=2247487402"