(Q6527941)

Immunoglobulin-like fold

1 reference

leptin receptor

1 reference

Fibronectin type III, protein family

1 reference

Immunoglobulin C2-set-like, ligand-binding domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Short hematopoietin receptor, family 1, conserved site, protein family

1 reference

Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity

1 reference

13 November 2019

1 reference

13 November 2019

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

8 April 2019

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

8 April 2019

Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

8 April 2019

Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

identical protein binding

IPI

1 reference

8 April 2019

Model for growth hormone receptor activation based on subunit rotation within a receptor dimer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

cytokine receptor activity

IPI

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48357&geneProductId=UniProtKB:P48357

transmembrane signaling receptor activity

1 reference

8 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

TAS

peptide hormone binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

integral component of membrane

IBA

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

2 references

1 reference

27 March 2018

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P48357&geneProductId=UniProtKB:P48357

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

basolateral plasma membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

external side of plasma membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

cholesterol metabolic process

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

negative regulation of hydrolase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

multicellular organism development

1 reference

8 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

negative regulation of gluconeogenesis

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

cell surface receptor signaling pathway

1 reference

8 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

1 reference

8 April 2019

Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

energy reserve metabolic process

IMP

1 reference

8 April 2019

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

negative regulation of autophagy

TAS

1 reference

8 April 2019

Leptin modulates autophagy in human CD4+CD25- conventional T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

leptin-mediated signaling pathway

3 references

glycogen metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

glial cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P48357

physically interacts with

metreleptin

object of statement has role

agonist

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107857

has part(s)

fibronectin type III

1 reference

immunoglobulin-like domain

1 reference

Long hematopoietin receptor, Gp130 family 2, conserved site

1 reference

Short hematopoietin receptor, family 1, conserved site

1 reference

Immunoglobulin C2-set-like, ligand-binding

1 reference