(Q7047475)

English

Noggin

mammalian protein found in Homo sapiens

symphalangism 1 (proximal)
uniprot:Q13253
NOG
noggin

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13253

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q13253

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

9 May 2019

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

protein binding

determination method

3 references

9 May 2019

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

A GDF5 point mutation strikes twice--causing BDA1 and SYNS2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

cytokine binding

determination method

1 reference

9 May 2019

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

extracellular space

determination method

4 references

27 March 2018

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Identification of mammalian noggin and its expression in the adult nervous system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

extracellular space

determination method

5 references

9 May 2019

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Identification of mammalian noggin and its expression in the adult nervous system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

biological process

pattern specification process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

axial mesoderm development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

ureteric bud development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of astrocyte differentiation

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

pituitary gland development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

lung morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of cartilage development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

somatic stem cell population maintenance

determination method

1 reference

9 May 2019

Bone morphogenetic protein antagonist gene NOG is involved in myeloproliferative disease associated with myelofibrosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

determination method

1 reference

9 May 2019

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

positive regulation of epithelial cell proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of cytokine activity

determination method

1 reference

9 May 2019

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

neural plate morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of cell differentiation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

anatomical structure formation involved in morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

mesoderm formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of apoptotic signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

embryonic digit morphogenesis

determination method

1 reference

9 May 2019

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

cellular response to BMP stimulus

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

in utero embryonic development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

somite development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of osteoblast differentiation

determination method

1 reference

9 May 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

embryonic skeletal system development

determination method

1 reference

9 May 2019

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

nervous system development

determination method

1 reference

9 May 2019

Identification of mammalian noggin and its expression in the adult nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of BMP signaling pathway

determination method

6 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

regulation of BMP signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

prostatic bud formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

limb development

determination method

1 reference

9 May 2019

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

central nervous system development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

cartilage development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

neural tube closure

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

brain development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of cell migration

determination method

1 reference

9 May 2019

CYR61 regulates BMP-2-dependent osteoblast differentiation through the {alpha}v{beta}3 integrin/integrin-linked kinase/ERK pathway

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

notochord morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

cell differentiation in hindbrain

determination method

1 reference

9 May 2019

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

mesenchymal cell differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

determination method

1 reference

9 May 2019

Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

neural tube development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

spinal cord development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

ureteric bud formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

epithelial to mesenchymal transition

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

middle ear morphogenesis

determination method

1 reference

9 May 2019

Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

embryonic skeletal joint morphogenesis

determination method

1 reference

9 May 2019

Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

urogenital system development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

endoderm formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of cardiac muscle cell proliferation

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

motor neuron axon guidance

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

dorsal/ventral pattern formation

determination method

1 reference

8 April 2019

Identification of mammalian noggin and its expression in the adult nervous system

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of canonical Wnt signaling pathway

determination method

1 reference

9 May 2019

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

face morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

osteoblast differentiation

determination method

3 references

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13253&geneProductId=UniProtKB:Q13253

determination method

endoderm development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of pathway-restricted SMAD protein phosphorylation

determination method

osteoblast differentiation

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

negative regulation of BMP signaling pathway

determination method

7 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13253

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000328181

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000328181

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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