(Q7062526)

English

Notch receptor 3

mammalian protein found in Homo sapiens

NOTCH3
neurogenic locus notch homolog protein 3
Notch homolog 3
notch 3

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Neurogenic locus Notch 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Notch-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Growth factor receptor cysteine-rich domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Notch, NODP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

based on heuristic

inferred from protein domain or family

Notch, NOD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Domain of unknown function DUF3454, notch, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EGF-like calcium-binding, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

protein binding

determination method

4 references

9 May 2019

Conserved signal peptide of Notch3 inhibits interaction with proteasome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Conserved signal peptide of Notch3 inhibits interaction with proteasome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

cadherin binding

determination method

1 reference

27 March 2018

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM47&geneProductId=UniProtKB:Q9UM47

determination method

identical protein binding

determination method

1 reference

9 May 2019

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

signaling receptor activity

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM47&geneProductId=UniProtKB:Q9UM47

determination method

cadherin binding

determination method

1 reference

9 May 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

endoplasmic reticulum membrane

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

receptor complex

determination method

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

plasma membrane

determination method

extracellular region

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

actin cytoskeleton

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

plasma membrane

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

CADASIL-associated Notch3 mutations have differential effects both on ligand binding and ligand-induced Notch3 receptor signaling through RBP-Jk

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

biological process

Notch signaling pathway

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

negative regulation of neuron differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

negative regulation of cell differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

glomerular capillary formation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

transcription, DNA-templated

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM47&geneProductId=UniProtKB:Q9UM47

determination method

artery morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

forebrain development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

neuron fate commitment

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

positive regulation of smooth muscle cell proliferation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

regulation of developmental process

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

positive regulation of transcription of Notch receptor target

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

Notch receptor processing, ligand-dependent

determination method

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM47&geneProductId=UniProtKB:Q9UM47

determination method

negative regulation of Notch signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

Notch signaling pathway

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM47

determination method

Gene Atlas image

PBB GE NOTCH3 203238 s at fs.png
732 × 530; 12 KB

0 references

EGF-type aspartate/asparagine hydroxylation site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

EGF-like calcium-binding, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Notch, NODP domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Notch, NOD domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

EGF-like, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Domain of unknown function DUF3454, notch

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

EGF-like calcium-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

EGF-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UM47

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000263388

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000263388

ENSP00000468879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468879

ENSP00000470661

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000470661

ENSP00000473138

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473138

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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