Wikidata

(Q7068151)

English

Nuclear mitotic apparatus protein 1

mammalian protein found in Homo sapiens

  • SP-H antigen
  • NMP-22
  • nuclear mitotic apparatus protein 1
  • structural nuclear protein
  • NUMA1
  • nuclear matrix protein-22
  • centrophilin stabilizes mitotic spindle in mitotic cells
In more languages

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
8 April 2019
stated in
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
A potential role for human cohesin in mitotic spindle aster assembly
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Rae1 interaction with NuMA is required for bipolar spindle formation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Rae1 interaction with NuMA is required for bipolar spindle formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
retrieved
8 April 2019
stated in
NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IPI
cell component
mitotic spindle astral microtubule
determination method
IDA
5 references
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
LGN blocks the ability of NuMA to bind and stabilize microtubules. A mechanism for mitotic spindle assembly regulation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved in Microtubule Stabilization in Mitotic Spindles
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Formation of spindle poles by dynein/dynactin-dependent transport of NuMA
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
mitotic spindle pole
determination method
IDA
IEA
IMP
17 references
retrieved
8 April 2019
stated in
Rae1 interaction with NuMA is required for bipolar spindle formation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IEA
retrieved
8 April 2019
stated in
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear mitotic apparatus protein (NuMA): spindle association, nuclear targeting and differential subcellular localization of various NuMA isoforms
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
RanGTP and CLASP1 cooperate to position the mitotic spindle
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organization
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Formation of spindle poles by dynein/dynactin-dependent transport of NuMA
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
cell cortex region
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IEA
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
spindle pole
determination method
IBA
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IEA
retrieved
8 April 2019
stated in
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IBA
biological process
regulation of mitotic spindle organization
determination method
IDA
IMP
5 references
retrieved
8 April 2019
stated in
Rae1 interaction with NuMA is required for bipolar spindle formation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Cortical dynein is critical for proper spindle positioning in human cells
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
The deubiquitinating enzyme complex BRISC is required for proper mitotic spindle assembly in mammalian cells
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
positive regulation of protein localization to cell cortex
determination method
IMP
6 references
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Cortical dynein and asymmetric membrane elongation coordinately position the spindle in anaphase
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Cell cycle-regulated membrane binding of NuMA contributes to efficient anaphase chromosome separation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
Cortical dynein is critical for proper spindle positioning in human cells
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
establishment of mitotic spindle orientation
determination method
IBA
IDA
IEA
IMP
ISS
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
ISS
retrieved
8 April 2019
stated in
NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IEA
retrieved
8 April 2019
stated in
LGN/mInsc and LGN/NuMA Complex Structures Suggest Distinct Functions in Asymmetric Cell Division for the Par3/mInsc/LGN and Gαi/LGN/NuMA Pathways
GOA
curator
UniProt
UniProt protein ID
Q14980
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14980
determination method
IBA
Gene Atlas image
PBB GE NUMA1 200747 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

RefSeq protein ID
Ensembl protein ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q7068151&oldid=2022909421"