(Q7394882)

English

Syntaxin 1A

mammalian protein found in Homo sapiens

STX1A
syntaxin-1A
neuron-specific antigen HPC-1
syntaxin 1A (brain)

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

SNARE subfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16623

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16623

synaptosomal vesicle fusion pore

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Syntaxin, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Target SNARE coiled-coil homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Syntaxin/epimorphin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium channel inhibitor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

transmembrane transporter binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein N-terminus binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

chloride channel inhibitor activity

determination method

1 reference

8 April 2019

Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

protein binding

determination method

7 references

8 April 2019

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

SUMOylation of Syntaxin1A regulates presynaptic endocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Munc18/Syntaxin interaction kinetics control secretory vesicle dynamics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

The septin CDCrel-1 binds syntaxin and inhibits exocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs).

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

NMR analysis of the structure of synaptobrevin and of its interaction with syntaxin

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein-macromolecule adaptor activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

myosin head/neck binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

ATP-dependent protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

calcium-dependent protein binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

integral component of membrane

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

plasma membrane

determination method

7 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

Role of H(abc) domain in membrane trafficking and targeting of syntaxin 1A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

secretory granule

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

extracellular region

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

3 references

16 July 2018

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

16 July 2018

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

intracellular organelle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

neuron projection

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

synaptobrevin 2-SNAP-25-syntaxin-1a complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

presynaptic membrane

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

postsynaptic density

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

presynaptic active zone membrane

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

nuclear membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

acrosomal vesicle

determination method

1 reference

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

integral component of synaptic vesicle membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

integral component of presynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

plasma membrane

determination method

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Role of H(abc) domain in membrane trafficking and targeting of syntaxin 1A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

endomembrane system

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

4 references

8 April 2019

Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Ca2+-dependent Phosphorylation of Syntaxin-1A by the Death-associated Protein (DAP) Kinase Regulates Its Interaction with Munc18

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

biological process

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16623&geneProductId=UniProtKB:Q16623

determination method

synaptic vesicle docking

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

secretion by cell

determination method

1 reference

8 April 2019

Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

regulation of insulin secretion

determination method

1 reference

8 April 2019

A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

positive regulation of neurotransmitter secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

response to gravity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

vesicle docking

determination method

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

positive regulation of excitatory postsynaptic potential

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

positive regulation of exocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

neurotransmitter transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

vesicle-mediated transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

calcium-ion regulated exocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

regulation of synaptic vesicle priming

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein localization to membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

modulation of excitatory postsynaptic potential

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

SNARE complex assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

cytokine-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

synaptic vesicle exocytosis

determination method

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

neurotransmitter secretion

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

glutamate secretion

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

protein sumoylation

determination method

1 reference

8 April 2019

SUMOylation of Syntaxin1A regulates presynaptic endocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

insulin secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

regulated exocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

hormone secretion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

synaptic vesicle endocytosis

determination method

1 reference

8 April 2019

SUMOylation of Syntaxin1A regulates presynaptic endocytosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16623

determination method

37941

0 references

Gene Atlas image

PBB GE STX1A 204729 s at fs.png
732 × 530; 11 KB

0 references

Syntaxin, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16623

Target SNARE coiled-coil homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16623

Syntaxin/epimorphin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16623

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000222812

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000222812

ENSP00000378585

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378585

ENSP00000378583

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378583

ENSP00000378584

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378584

0 references

Transporter Classification Database ID

1 reference

Transporter Classification database

13 March 2020

0 references

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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