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ABL1 SNX2::ABL1
genetic variant
SNX2-ABL1 Fusion
SNX2-ABL1
SNX2::ABL1
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Statements
instance of
transcript fusion
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
chromosome
human chromosome 5
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
human chromosome 9
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
genomic start
122110691
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
133738150
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
genomic end
122135550
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
133763062
genomic assembly
Genome assembly GRCh37
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
biological variant of
ABL1
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
negative therapeutic predictor for
dasatinib monohydrate
determination method
CIViC evidence level C
rating
CIViC 2-star trust rating
medical condition treated
precursor B lymphoblastic lymphoma/leukemia
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7241
stated in
Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript.
dasatinib monohydrate
determination method
CIViC evidence level D
rating
CIViC 3-star trust rating
medical condition treated
precursor B lymphoblastic lymphoma/leukemia
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7655
stated in
Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
imatinib
determination method
CIViC evidence level D
rating
CIViC 3-star trust rating
medical condition treated
precursor B lymphoblastic lymphoma/leukemia
1 reference
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7655
stated in
Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
positive diagnostic predictor for
B-lymphoblastic leukemia/lymphoma, BCR-ABL1–like
determination method
CIViC evidence level C
rating
CIViC 3-star trust rating
2 references
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/9177
stated in
Characterization of pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia with kinase fusions in Japan
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/9178
stated in
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
negative prognostic predictor for
precursor B lymphoblastic lymphoma/leukemia
determination method
CIViC evidence level C
rating
CIViC 1-star trust rating
2 references
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7694
stated in
SNX2-ABL1-positive acute lymphoblastic leukemia possibly has a poor prognosis
curator
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/evidence/7744
stated in
Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript.
Identifiers
CIViC variant ID
2678
1 reference
stated in
CIViC database
retrieved
23 May 2022
reference URL
https://civic.genome.wustl.edu/links/variants/2678
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