(Q100152389)

English

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9665413)

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Statements

biological process

1 reference

8 July 2022

Signaling by ERBB2 ECD mutants

1 reference

13 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-9665413

1 reference

8 July 2022

GRB2-1:SOS1 [cytosol]

1

object has role

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1 [plasma membrane]

1

object has role

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

1

object has role

1 reference

8 July 2022

Activating HER2 mutations in HER2 gene amplification negative breast cancer

1 reference

8 July 2022

Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

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