(Q50254938)

English

GRB2-1:SOS1 [cytosol]

An instance of macromolecular complex in Homo sapiens with Reactome ID (R-HSA-109797)

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Statements

1 reference

8 July 2022

FGFR4 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR

1 reference

8 July 2022

NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

NTRK3 binds GRB2:SOS1 through SHC1

1 reference

8 July 2022

p-6Y-ERBB2 TMD/JMD mutants (RAS):EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR2:p-SHC1 binds GRB2:SOS1

1 reference

8 July 2022

GRB2:SOS1 complex binds to mutant PDGFR receptor

1 reference

8 July 2022

Activated FGFR3:p-SHC1 binds GRB2:SOS1

1 reference

8 July 2022

KIT mutants bind GRB2-SOS

1 reference

8 July 2022

2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 KD mutants and EGFR bind GRB2:SOS1

1 reference

8 July 2022

Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR2 mutants:p-FRS2 binds GRB2-SOS1

1 reference

8 July 2022

Phosphorylated SHC recruits GRB2:SOS1

1 reference

8 July 2022

GRB2:SOS1 binds to phosphorylated heterodimers of ERBB2 ECD mutants and EGFR

1 reference

8 July 2022

GRB2:SOS1 complex binds to EGF:EGFR complex

1 reference

8 July 2022

Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

1 reference

8 July 2022

Binding of GRB2:SOS1 complex to phosphorylated EGFRvIII

1 reference

8 July 2022

Activated FGFR4 mutants:p-FRS2 binds GRB2-SOS1

1 reference

8 July 2022

BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane]

1 reference

8 July 2022

p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR3:pFRS binds GRB2:SOS1

1 reference

8 July 2022

FGFR2 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2-1:SOS1:p-Y427-SHC1 [cytosol]

1 reference

8 July 2022

HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

NTRK2-phosphorylated FRS2 binds GRB2

1 reference

8 July 2022

Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants and EGFR bind GRB2:SOS1

1 reference

8 July 2022

p-KIT mutants:GRB2:SOS [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane]

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 TMD/JMD mutants recruit GRB2:SOS1 through SHC1

1 reference

8 July 2022

Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex

1 reference

8 July 2022

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2-1:SOS1 binds p-3Y-SHC1

1 reference

8 July 2022

Activated FGFR4:p-FRS binds GRB2:SOS1

1 reference

8 July 2022

Activated FGFR4:p-SHC1 binds GRB2:SOS1

1 reference

8 July 2022

GRB2-1:SOS1:p-3Y-SHC1 [cytosol]

1 reference

8 July 2022

1 reference

8 July 2022

EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

p-5Y-EGFRvIII:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

p-6Y-ERBB2 TMD/JMD mutants:Ligand-Activated p-EGFR,p-ERBB3,(p-ERBB4):p-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1

1 reference

8 July 2022

GRB2:SOS1 complex binds to PDGFRA extracellular domain dimers

1 reference

8 July 2022

Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Phosphorylated SHC1 in complex with p-5Y-EGFRvIII recruits GRB2:SOS1 complex

1 reference

8 July 2022

Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR1 mutants:p-FRS2 binds GRB2-SOS1

1 reference

8 July 2022

GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol]

1 reference

8 July 2022

GRB2-1:SOS1 binds p-Y427-SHC1

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 KD mutants recruit GRB2:SOS1 through SHC1

1 reference

8 July 2022

Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

SHC1 bound to activated NTRK2 recruits GRB2:SOS1

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 KD mutants:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

p-ERBB2 homodimer:p-Y349,Y350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]

1 reference

8 July 2022

Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers

1 reference

8 July 2022

Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

SHC1-2 bound to MET recruits GRB2:SOS1

1 reference

8 July 2022

Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 homodimer

1 reference

8 July 2022

GRB2-1:SOS1:p-Y-SHC [cytosol]

1 reference

8 July 2022

GRB2-1:SOS1 binds p-Y-SHC

1 reference

8 July 2022

p-6Y-ERBB2 ECD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer

1 reference

8 July 2022

GRB2:SOS1:p-KIT complex [plasma membrane]

1 reference

8 July 2022

p-6Y-ERBB2 KD mutants:EGF:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

BDNF,NTF4:p-5Y-NTRK2:p-Y317-SHC1-2,(p-Y272-SHC1-3):GRB2-1:SOS1 [plasma membrane]

1 reference

8 July 2022

Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers

1 reference

8 July 2022

GRB2:SOS interacts with p-KIT

1 reference

8 July 2022

Activated FGFR2:pFRS binds GRB2:SOS1

1 reference

8 July 2022

EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:phospho-SHC1 binds GRB2:SOS1

1 reference

8 July 2022

FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

p-5Y-EGFRvIII:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane]

1 reference

8 July 2022

HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane]

1 reference

8 July 2022

Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR recruit GRB2:SOS1 through SHC1

1 reference

8 July 2022

Activated MET recruits GRB2-1:SOS1

1 reference

8 July 2022

EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1 binds to HBEGF:p-Y-EGFR

1 reference

8 July 2022

Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

Activated FGFR1:p-FRS binds GRB2:SOS1

1 reference

8 July 2022

GRB2-1:SOS1 binds p-IRS1,p-IRS2

1 reference

8 July 2022

Interaction of GRB2:SOS complex with p-SHC1

1 reference

8 July 2022

Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1

1 reference

8 July 2022

p-SHC1:GRB2:SOS [cytosol]

1 reference

8 July 2022

p-11Y PDGFRA extracellular domain dimers:GRB2:SOS1 [endoplasmic reticulum membrane]

1 reference

8 July 2022

EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-CRKL:RAPGEF1:p-Y-SHC1:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane]

1 reference

8 July 2022

FGFR1 mutants:p-FRS2:GRB2:SOS1 [plasma membrane]

1 reference

8 July 2022

GRB2:SOS1 complex binds to the active receptor

1 reference

8 July 2022

Activated FGFR1:p-SHC1 binds GRB2:SOS1

1 reference

8 July 2022

GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers

1 reference

8 July 2022

1 reference

8 July 2022

https://identifiers.org/reactome:R-HSA-109797

1 reference

8 July 2022

Growth factor receptor bound protein 2

quantity

1

1 reference

8 July 2022

SOS Ras/Rac guanine nucleotide exchange factor 1

quantity

1

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q50254938)

GRB2-1:SOS1 [cytosol]

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