(Q50288599)

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Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-1225950)

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8 July 2022

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-1225950

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8 July 2022

GRB2-1:SOS1 [cytosol]

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8 July 2022

Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane]

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8 July 2022

Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane]

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8 July 2022

Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition

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8 July 2022

EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer

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8 July 2022

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

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8 July 2022

Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain

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8 July 2022

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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8 July 2022

Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants

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8 July 2022

Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma

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8 July 2022

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

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8 July 2022

Association with HSP90 inhibits Cbl-mediated down-regulation of mutant epidermal growth factor receptors.

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8 July 2022

Identifiers

1 reference

8 July 2022

(Q50288599)

Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants

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