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GRB2:SOS1 complex binds to mutant PDGFR receptor
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-9672164)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
part of
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
exact match
https://identifiers.org/reactome:R-HSA-9672164
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
has part(s)
GRB2-1:SOS1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
p-11Y PDGFR mutant receptor dimers [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
p-11Y PDGFR mutatnt receptors:GRB2:SOS1 [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
cites work
PDGFRA activating mutations in gastrointestinal stromal tumors.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
Different inhibitory effect of imatinib on phosphorylation of mitogen-activated protein kinase and Akt and on proliferation in cells expressing different types of mutant platelet-derived growth factor receptor-alpha
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
Gastrointestinal stromal tumours: origin and molecular oncology.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders.
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
Identifiers
Reactome ID
R-HSA-9672164
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-9672164
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