(Q36564274)

English

Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation

scientific article published on December 1996

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

alphaPDGFR-SHP-2 complex

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

Grb2-SHP-2 complex

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

C E Bazenet

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

J A Gelderloos

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

A Kazlauskas

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

1 December 1996

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Molecular and Cellular Biology

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

16

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

12

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

6926-6936

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

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30 September 2017

Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1 reference

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30 September 2017

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells

1 reference

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30 September 2017

Receptor tyrosine kinases and their targets

1 reference

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30 September 2017

SH2/SH3 signaling proteins

1 reference

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30 September 2017

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras

1 reference

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30 September 2017

Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

1 reference

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30 September 2017

Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins.

1 reference

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Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1 reference

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30 September 2017

Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.

1 reference

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30 September 2017

Modular binding domains in signal transduction proteins

1 reference

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30 September 2017

Platelet-derived growth factor receptor signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Differential requirement of a motif within the carboxyl-terminal domain of alpha-platelet-derived growth factor (alpha PDGF) receptor for PDGF focus forming activity chemotaxis, or growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Identification of a putative Syp substrate, the PDGF beta receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Protein modules and signalling networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains

1 reference

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30 September 2017

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation

1 reference

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30 September 2017

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Human microvascular endothelial cells express receptors for platelet-derived growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF

1 reference

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30 September 2017

Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction

1 reference

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Cell death and control of cell survival in the oligodendrocyte lineage

1 reference

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30 September 2017

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1 reference

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30 September 2017

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

30 September 2017

Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo

1 reference

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30 September 2017

PDGF-AB requires PDGF receptor alpha-subunits for high-affinity, but not for low-affinity, binding and signal transduction.

1 reference

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28 June 2018

Expression of functionally intact PDGF-alpha receptors in highly metastatic 3LL Lewis lung carcinoma cells

1 reference

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Differences in substrate specificities of alpha and beta platelet-derived growth factor (PDGF) receptors. Correlation with their ability to mediate PDGF transforming functions

1 reference

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28 June 2018

Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant

1 reference

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The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with rasGAP.

1 reference

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28 June 2018

SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases

1 reference

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28 June 2018

Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin.

1 reference

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28 June 2018

Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis

1 reference

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28 June 2018

Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

28 June 2018

Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture.

1 reference

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28 June 2018

Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-alpha and their receptors in human malignant glioma cell lines

1 reference

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28 June 2018

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1 reference

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28 June 2018

Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types

1 reference

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28 June 2018

Mouse platelet-derived growth factor alpha receptor: sequence, tissue-specific expression and correlation with metastatic phenotype

1 reference

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28 June 2018

PDGF alpha- and beta-receptors activate unique and common signal transduction pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

28 June 2018

Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: Evidence for a developmental shift from an autocrine to a paracrine mode of action

1 reference

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28 June 2018

Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

21 September 2018

Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=231696

21 September 2018

A role for platelet-derived growth factor in normal gliogenesis in the central nervous system

1 reference

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L-histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential

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21 September 2018

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-derived growth factor promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor ceil

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PDGF A-chain gene is expressed by mammalian neurons during development and in maturity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of platelet-derived growth factor (PDGF) and PDGF alpha- and beta-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

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inferred from PubMed ID database lookup

Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development

1 reference

https://pubmed.ncbi.nlm.nih.gov/8943348

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.16.12.6926

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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