(Q39141642)

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PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations

scientific article published on 10 June 2013

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Europe PubMed Central

PubMed publication ID

9 September 2017

PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations (English)

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Europe PubMed Central

PubMed publication ID

9 September 2017

transmembrane protein

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Jean-Baptiste Demoulin

9

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Europe PubMed Central

PubMed publication ID

9 September 2017

author name string

A I Velghe

1

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Europe PubMed Central

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9 September 2017

S Van Cauwenberghe

2

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Europe PubMed Central

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9 September 2017

A A Polyansky

3

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Europe PubMed Central

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9 September 2017

D Chand

4

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Europe PubMed Central

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9 September 2017

C P Montano-Almendras

5

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Europe PubMed Central

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9 September 2017

S Charni

6

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Europe PubMed Central

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9 September 2017

B Hallberg

7

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9 September 2017

A Essaghir

8

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9 September 2017

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publication date

10 June 2013

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9 September 2017

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9 September 2017

33

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9 September 2017

20

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Europe PubMed Central

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9 September 2017

2568-2576

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Europe PubMed Central

PubMed publication ID

9 September 2017

Role of platelet-derived growth factors in physiology and medicine

1 reference

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Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail.

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New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases

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PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

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Tyrosine kinase gene fusions in cancer: translating mechanisms into targeted therapies

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

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Novel imatinib-sensitive PDGFRA-activating point mutations in hypereosinophilic syndrome induce growth factor independence and leukemia-like disease

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Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization.

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Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

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A human brain tumor-derived PDGFR-alpha deletion mutant is transforming

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PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas

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Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders

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Safety and efficacy of imatinib in chronic eosinophilic leukaemia and hypereosinophilic syndrome: a phase-II study

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Prognostic but not predictive role of platelet-derived growth factor receptors in patients with recurrent glioblastoma

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Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide

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Mutation and expression of PDGFRA and KIT in malignant peripheral nerve sheath tumors, and its implications for imatinib sensitivity

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Novel missense mutations in the tyrosine kinase domain of the platelet-derived growth factor receptor alpha(PDGFRA) gene in childhood acute myeloid leukemia with t(8;21)(q22;q22) or inv(16)(p13q22).

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21 January 2018

Patterns of somatic mutation in human cancer genomes

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21 January 2018

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

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21 January 2018

Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas

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21 January 2018

Critical role of the platelet-derived growth factor receptor (PDGFR) beta transmembrane domain in the TEL-PDGFRbeta cytosolic oncoprotein

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21 January 2018

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation

1 reference

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21 January 2018

Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization

1 reference

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21 January 2018

Hydrophobic Matching Controls the Tilt and Stability of the Dimeric Platelet-derived Growth Factor Receptor (PDGFR) Transmembrane Segment

1 reference

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21 January 2018

Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase

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21 January 2018

Architecture and membrane interactions of the EGF receptor

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Conformational coupling across the plasma membrane in activation of the EGF receptor

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Structural basis for activation of the receptor tyrosine kinase KIT by stem cell factor

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21 January 2018

The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo

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21 January 2018

Ligand-induced recruitment of Na+/H+-exchanger regulatory factor to the PDGF (platelet-derived growth factor) receptor regulates actin cytoskeleton reorganization by PDGF.

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21 January 2018

PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling

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Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles

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21 January 2018

Human non-synonymous SNPs: server and survey

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21 January 2018

Genetic heterogeneity of diffuse large B-cell lymphoma

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The fusion proteins TEL-PDGFRbeta and FIP1L1-PDGFRalpha escape ubiquitination and degradation

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A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9

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ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human hematopoietic progenitor cell proliferation and differentiation into eosinophils: the role of nuclear factor-κB.

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Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

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Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells

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Multiple oligomerization domains of KANK1-PDGFRβ are required for JAK2-independent hematopoietic cell proliferation and signaling via STAT5 and ERK.

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Multistate organization of transmembrane helical protein dimers governed by the host membrane

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Immunoglobulin-like domain 4-mediated receptor-receptor interactions contribute to platelet-derived growth factor-induced receptor dimerization

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31 March 2020

Identifiers

10.1038/ONC.2013.218

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 September 2017

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