(Q42037674)

15 October 2017

The neuroblastoma ALK(I1250T) mutation is a kinase-dead RTK in vitro and in vivo (English)

1 reference

15 October 2017

1 reference

9

Ruth H Palmer

1 reference

15 October 2017

Christina Schönherr

1

1 reference

15 October 2017

Kristina Ruuth

2

1 reference

15 October 2017

Therese Eriksson

3

1 reference

15 October 2017

Yasuo Yamazaki

4

1 reference

15 October 2017

Christian Ottmann

5

1 reference

15 October 2017

Valerie Combaret

6

1 reference

15 October 2017

Marc Vigny

7

1 reference

15 October 2017

Sattu Kamaraj

8

1 reference

15 October 2017

Bengt Hallberg

10

1 reference

15 October 2017

language of work or name

1 reference

1 August 2011

1 reference

15 October 2017

Translational Oncology

1 reference

15 October 2017

4

1 reference

15 October 2017

4

1 reference

15 October 2017

258-265

1 reference

The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking

15 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Appearance of the novel activating F1174S ALK mutation in neuroblastoma correlates with aggressive tumor progression and unresponsiveness to therapy

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

EML4-ALK mutations in lung cancer that confer resistance to ALK inhibitors.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Defining the conserved internal architecture of a protein kinase.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Anaplastic lymphoma kinase: signalling in development and disease

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Activating mutations in ALK provide a therapeutic target in neuroblastoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Oncogenic mutations of ALK kinase in neuroblastoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Identification of ALK as a major familial neuroblastoma predisposition gene

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Anaplastic lymphoma kinase proteins in growth control and cancer

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Neuroblastoma: biological insights into a clinical enigma

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

Ligand-induced transphosphorylation between different FGF receptors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the mouse ALK RTK.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3140014

High incidence of DNA mutations and gene amplifications of theALKgene in advanced sporadic neuroblastoma tumours

17 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21804922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21804922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1593/TLO.11139

1 reference

15 October 2017

1 reference

15 October 2017

1 reference