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GRB2:SOS1 complex binds to EGF:EGFR complex
An instance of the biological reaction in Homo sapiens with Reactome ID (R-HSA-177943)
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Statements
instance of
biological process
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
part of
GRB2 events in EGFR signaling
1 reference
stated in
Reactome
retrieved
13 July 2022
Reactome ID
R-HSA-177943
found in taxon
Homo sapiens
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
exact match
https://identifiers.org/reactome:R-HSA-177943
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
has part(s)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
GRB2-1:SOS1 [cytosol]
quantity
1
object has role
reactant
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane]
quantity
1
object has role
product
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
cites work
Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
Identifiers
Reactome ID
R-HSA-177943
1 reference
stated in
Reactome
retrieved
8 July 2022
Reactome ID
R-HSA-177943
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